Sodium Chloride → HCID 18768042, compound

Participants

Reaction Steps

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (52 mg, 0.27 mmol) was added to a mixture of 5-bromo-2-(4-carboxyanilino)-4-(4-fluoroanilino)pyrimidine (Method 7; 100 mg, 0.25 mmol), N-(3-aminopropyl)-2-pyrrolidinone (38 mg, 0.27 mmol) and 1-hydroxybenzotriazole (44 mg, 0.32 mmol) in DMF (0.5 ml). The mixture was stirred for 16 hours and then a 1:1 mixture of saturated sodium chloride solution and water (10 ml) was added. The precipitated solid was collected by filtration and dried to a constant weight in a vacuum oven at 40° C. to give the product as an off-white solid (98 mg, 75%). MS (MH+): 528; HPLC (RT): 4.01.

Provenance & Evidence