4-Methoxyphenol → HCID 79080957, compound

HRID 480018Notes

Reaction equation

HRID 480018 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[N:7]=[C:6]([O:18][C:15]2[CH:16]=[CH:17][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[C:5]([F:9])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 79080957HCID 79080957, compound

Procedure

Using an analogous method to that described in Method 28, but starting from 2,4-dichloro-5-fluoropyrimidine and 4-methoxyphenol, the product was obtained. NMR: 3.84 (s, 3H), 6.79-7.00 (m, 2H), 7.06-7.18 (m, 2H), 8.31-8.36 (m, 1H); MS (M+): 254, 256.

Workup

  1. customthe product was obtained

Sources & evidence

ORD record
ord-652462c5f0264605b5909cd01f8ea7cb
Source dataset
uspto-grants-2003_11
Patent number
US06649608B2

Reaction notes

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