Ammonium formate → HCID 18768328, compound

Participants

Reaction Steps

A solution of 4.29 g (13.11 mmol) of 1-{3-[benzyl(methyl)amino]propyl}-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione in a mixture of 50 ml of methanol and 10 ml of tetrahydrofuran is admixed with 5.6 mg of 10% palladium-on-carbon. Over a period of 45 minutes, three portions of in total 8.61 g (136.6 mmol) of ammonium formate are then added. After the addition has ended, the mixture is heated at reflux for 1.5 hours. After cooling, the mixture if filtered through a little kieselguhr and the solvent is removed under reduced pressure. This gives 2.24 g (9.44 mmol, 72% yield) of the product as a colourless solid.

Provenance & Evidence