HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Product | 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine | HCID 11484042 | — |
Reaction Steps
A mixture of 3 g (0.015 mole) of the product of preparation 1, 1.5 g (0.025 mole) of triethylamine and 2.34 g (0.015 mole) of 6-chloronicotinamide is heated to 80° C. for 18 hours in 60 ml of dimethylformamide. After cooling, water is added and the product filtered. This produces 2.8 g of the named compound M. P. 255° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06649627B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-b1f35fc78bbb4ba7b66e6961007b4b56 |
| Source note | uspto-grants-2003_11 |