Water → HCID 17887112, compound

Participants

Reaction Steps

A solution containing 0.7 g (0.0034 mole) of the product of preparation 1, 0.53 g (0.0023 mole) of 2-bromomethyl-5-methoxycarbonyl-pyridine (prepared using the procedure described in J. Med. Chem., 1992, 3, 490-501), and 0.26 ml (0.0025 mole) of triethylamine in 10 ml of dimethylformamide is heated at 40° C. for 2 hours. It is then poured into water, extracted with ethyl acetate and the reaction product purified by flash chromatography (eluant: ethyl acetate). The named compound is obtained: M. P. 110-112° C.

Provenance & Evidence