反应详情

温度

80 °C

To a solution of 2-amino-5-bromopyrazine (642 mg) in dimethoxyethane (40 mL) was added 3-methoxyphenylboronic acid (560 mg), 1.5N aqueous sodium carbonate solution (4 mL) and tetrakis(triphenylphosphine) palladium (0) (86 mg). The mixture was stirred at 80° C. for 6 hours. To the reaction mixture was added water (20 mL) and the whole was extracted with ethyl acetate (50 mL×3). The extract was washed with saturated saline solution and then dried over anhydrous Na2SO4. The concentration of the solvent left a crystal residue, which was washed with ethyl ether (10 mL) to give the subject compound (760 mg).

1. extractionthe whole was extracted with ethyl acetate (50 mL×3)
2. washThe extract was washed with saturated saline solution
3. dry with materialdried over anhydrous Na2SO4
4. waitThe concentration of the solvent left a crystal residue, which
5. washwas washed with ethyl ether (10 mL)