反应详情

1′-benzyl-6-ethylspiro[isobenzofuran-1(3H),4′-piperidine]-3-one hydrochloride (400 mg) was dissolved in methanol (10 mL) and 10% palladium carbon was added. The mixture was stirred under a hydrogen atmosphere for 1.5 hours. After the palladium carbon was removed by filtration, the filtrate was concentrated to give a residue, which was subjected to crystallization with methanol-ethyl ether to give the subject compound (222 mg).

1. customAfter the palladium carbon was removed by filtration
2. concentrationthe filtrate was concentrated
3. customto give a residue, which
4. customwas subjected to crystallization with methanol-ethyl ether