HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → (2R,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid methyl ester Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | (2R,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid | HCID 638739 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid methyl ester Hydrochloride | HCID 69746370 | — |
Reaction Steps
A mixture of (2R,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (200 mg, 1.0 mmol, Sigma Chemical Co. (St. Louis, Mo.), chlorotrimethylsilane (500 mg, 4.6 mmol) and methanol (2 mL) was heated at reflux for 5.5 hours and concentrated to a foam: Yield 244 mg, 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06649634B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-68e6644c97174533a932adf574bfc742 |
| Source note | uspto-grants-2003_11 |