反应详情

Ethyl 3-methyl-4-isoxazolecarboxylate (1.3 g) is stirred at room temperature overnight in 5 mL of ethanol and 10 mL of 2.5 N sodium hydroxide. Dilution with water, cooling in ice, and acidification to pH 2 with 6 N hydrochloric acid precipitates an off-white solid which is collected by vacuum filtration, washed with ethanol/water, and dried under vacuum to give 1.0 g of 3-methyl-4-isoxazolecarboxylic acid.

1. customacidification to pH 2 with 6 N hydrochloric acid precipitates an off-white solid which
2. filtrationis collected by vacuum filtration
3. washwashed with ethanol/water
4. customdried under vacuum