Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 480091Generated: October 30, 2026

4-(Trifluoromethyl)aniline → HCID 178522271, compound

https://huagongshe.com/reaction/480091

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)anilineHCID 9964—
ReactantEthyl orthoformateHCID 31214—
ReactantHCID 178428610HCID 178428610—
ReactantHCID 178428611HCID 178428611—
ReactantHCID 178522055HCID 178522055—
ProductHCID 178522271HCID 178522271—

Reaction Steps

By substituting the appropriate amines for 4-(trifluoromethyl)aniline in a, and then by substituting triethyl-2-chloroorthobenzoate for triethylorthoformate in b, the identical process of a gives 5-(2-chlorophenyl)-3-cyclopropyl-4-[4-(trifluoromethyl) phenylaminocarbonyl]pyrazole, 5-(2-chlorophenyl)-3-cyclopropyl-4-(pyrid-2-aminocarbonyl)pyrazole, and 5-(2-chlorophenyl)-3-cyclopropyl-4-[3-methyl-4-(trifluoromethyl) phenylaminocarbonyl]pyrazole and 5-(2-chlorophenyl)-3-cyclopropyl-4-[3-methyl-4-(trifluoromethyl-sulfonyl)phenylaminocarbonyl]pyrazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06649635B2
Source datasetuspto-grants-2003_11
ORD IDord-81b2c4bc7f6d4079b02a10b5509fe486
Source noteuspto-grants-2003_11