HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-adamantane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1,3-Adamantanedicarboxylic acid | HCID 64339 | — |
| Reactant | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| Product | 3-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-adamantane-1-carboxylic acid | HCID 18767666 | — |
Reaction Steps
Symmetrical anhydride prepared from adamantane 1,3-dicarboxylic acid using DIC in DMF was coupled to 1,3-dipropyl-5,6-diaminouracil.HCl. The product was cyclized using KOH in isopropanol/water. Mass (ES+ 415)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06649600B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-666e95f2df274a3f9358500c1e0c51f2 |
| Source note | uspto-grants-2003_11 |