HCID 2724874, compound → HCID 69557076, compound

HRID 480257Notes

Reaction equation

HRID 480257 reaction equation
[NH2:1][C@@H:2]([CH2:6][NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4].[ClH:15].[CH3:16]O>>[ClH:15].[ClH:15].[CH3:16][O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 2724874HCID 2724874, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 69557076HCID 69557076, compoundYield 97.5%

Procedure

To 1N HCl/MeOH (50 mL) at 0° C. was added (S)-2-Amino-3-benzylamino-propanoic acid(0.5 g, 2.57 mmol). Reaction was stirred at room temperature overnight. Volatiles were removed to give the product 2-Amino-3-benzylamino-propanoic acid methyl ester dihydrochloride salt as a white solid (0.7 g, 97.5%). MS: m/z=209 M+1

Workup

  1. customReaction
  2. customVolatiles were removed

Sources & evidence

ORD record
ord-dd87e17f1dd145dca61d0267d38c90b4
Source dataset
uspto-grants-2003_11
Patent number
US06649642B2

Reaction notes

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