1-(2-Fluorophenyl)-1,3-propanediamine → 4-fluorophenyl-3-methyl-6-(4-pyridyl)-4(3H)-pyrimidinone

HRID 480419Notes

Reaction equation

HRID 480419 reaction equation
FC1C=CC([C:8]2[C:9](=[O:23])[N:10]([CH3:22])[C:11](SC)=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=CC=1.[F:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1C(N)CCN>>[F:24][C:25]1[CH:30]=[CH:29][C:28]([C:11]2[N:10]([CH3:22])[C:9](=[O:23])[CH:8]=[C:13]([C:14]3[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=3)[N:12]=2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 223465761-(2-Fluorophenyl)-1,3-propanediamineHCID 223466205-(4-fluorophenyl)-3-methyl-2-methylthio-6-(4-pyridyl)-4(3H)-pyrimidinone

Product 1

HCID 539682114-fluorophenyl-3-methyl-6-(4-pyridyl)-4(3H)-pyrimidinone

Procedure

2-34 2-((3-Amino-3-(2-fluorophenyl)propyl-amino)-5-(4-fluorophenyl-3-methyl-6-(4-pyridyl)-4(3H)-pyrimidinone was prepared from 5-(4-fluorophenyl)-3-methyl-2-methylthio-6-(4-pyridyl)-4(3H)-pyrimidinone and 1-(2-fluorophenyl)-1,3-propanediamine according to the General Procedure. The reaction was done at 190μ C. for 3 h. MS (m/z): 448.1 (M+H)+; C25H23F2N5O requir. 447.5 (free base).

Sources & evidence

ORD record
ord-63d9f9fcfc684c5bb3610fa1552d8e31
Source dataset
uspto-grants-2003_11
Patent number
US06649604B2

Reaction notes

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