Methanol → HCID 18767998, compound

HRID 480428Notes

Reaction equation

HRID 480428 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:6]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[N:5]=[C:4]1[S:23][CH3:24])[CH3:2].S([O-])(O[O-])(=O)=O.[K+].[K+].[OH2:33].C[OH:35]>>[CH2:1]([N:3]1[C:8](=[O:9])[C:7]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:6]([C:17]2[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=2)[N:5]=[C:4]1[S:23]([CH3:24])(=[O:35])=[O:33])[CH3:2]

Participants

5

Reactant 4

HCID 887MethanolHCID 962WaterHCID 10313463Potassium peroxymonosulphateHCID 18767913HCID 18767913, compound

Product 1

HCID 18767998HCID 18767998, compound

Procedure

A mixture of 3-ethyl-5-(4-fluorophenyl)-2-methylthio-6-(4-pyridyl)-4(3H)-pyrimidinone (300 mg, 0.88 mmol) and OxoneR potassium peroxymonosulfate, 2.54 g, 4.14 mmol) in methanol (71 ml) and water (33 ml) was stirred for 14 h. The solvent was concentrated to about 35 ml, followed by extraction with dichloromethane, drying and evaporation. The resulting white solid was used without purification in the next step.

Workup

  1. concentrationThe solvent was concentrated to about 35 ml
  2. extractionfollowed by extraction with dichloromethane
  3. customdrying
  4. customevaporation
  5. customThe resulting white solid was used without purification in the next step

Sources & evidence

ORD record
ord-1b31705b09d5405fbce1477c7933622a
Source dataset
uspto-grants-2003_11
Patent number
US06649604B2

Reaction notes

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