Acetic Anhydride → HCID 54547025, compound

HRID 480431Notes

Reaction equation

HRID 480431 reaction equation
[NH2:1][C@H:2]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:3][CH2:4][NH:5][C:6]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[C:8]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[N:7]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34]>CO>[C:33]([NH:1][C@H:2]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:3][CH2:4][NH:5][C:6]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]([C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)=[C:8]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[N:7]=1)(=[O:35])[CH3:34]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 53755089HCID 53755089, compound

Product 1

HCID 54547025HCID 54547025, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-(((S)-3-amino-3-phenylpropyl) -amino)-5-(4-fluorophenyl)-3-methyl-6-(4-pyridyl)-4(3H)-pyrimidinone (23.8 mg, 0.055 mmol) and acetic anhydride (20 μl, 0.21 mmol) in methanol(1 ml) was kept for 30 min at room temperature. Evaporation was followed by column chromatography (dichloromethane-methanol-ammonium hydroxide=93:7:0.7) to provide the title compound. MS (m/z): 472.2 (M+H)+; C27H26FN5O2requir. 471.5.

Workup

  1. customEvaporation

Sources & evidence

ORD record
ord-974ba5e1c6264a1e9c6b4e8402538340
Source dataset
uspto-grants-2003_11
Patent number
US06649604B2

Reaction notes

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