Tetrabutylammonium Fluoride → HCID 178450050, compound

Participants

Reaction Steps

A solution of tetrabutylammonium fluoride in THF (1M:3 mL) was added to a solution of 2-methyl-1-(6-(5-trimethylsilyl-1H-1,2,3-triazol-4-yl)-2-naphthyl)-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (820 mg) in THF (3 mL) and the mixture was stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried and concentrated. The residue was purified by column chromatography (eluent; hexane:THF=4:1) and crystallized from ethyl acetate-hexane to give the titled compound (703 mg) as a colorless powder.

Provenance & Evidence