Ammonium Chloride → HCID 178450035, compound

Participants

Reaction Steps

n-Butyl-lithium in hexane (1.6M; 41 mL) was added to a solution of 8-bromo-2,3-dihydro-1H-benzo[f]chromene (13.35 g) in THF (250 ml) at −78° C. and stirred at the same temperature for 30 min. A solution of 4-formyl-1-trityl-1H-imidazole (16.83 g) in THF (150 ml) was added to the mixture and the whole was allowed to room temperature. Aqueous ammonium chloride solution was added to the mixture and extracted with ethyl acetate. The organic layer was washed with brine, dried and concentrated. The residue was washed with ethyl acetate to give the titled compound (11.80 g) as a colorless solid.

Provenance & Evidence