Diisopropyl Ether → HCID 178486612, compound

Participants

Reaction Steps

1-(6,7-dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol(485 mg) and (−)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide (653 mg) were dissolved in methanol (4 mL). Diisopropyl ether (3 mL) was added and the resulting clear solution was left at room temperature for 5 h to give needles. The needles were washed with a mixed solution of methanol-diisopropyl ether (1:3, 4 mL) and diisopropyl ether (1 mL) and then dried to give the titled compound (362 mg) as colorless needles. Optical purity; >99% ee (Chiralcel OJ-R, manufactured by Daicel Chemical Industries, Ltd.).

Provenance & Evidence