反应详情

温度

60 °C

A mixture of 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-N-isopropyl-2-naphthamide (16.6 g) and pyridinium chloride (6.46 g) in methanol (84 mL) was heated at 60° C. for 3 h. The solvent was evaporated and the residue was dissolved in chloroform, which was washed with saturated sodium bicarbonate solution, dried and concentrated. The residue was purified by column chromatography (eluent; CHCl3: 8% methanolic ammonia=19:1→9:1) to give the titled compound (8.3 g) as a colorless powder.

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in chloroform
3. washwhich was washed with saturated sodium bicarbonate solution
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by column chromatography (eluent; CHCl3: 8% methanolic ammonia=19:1→9:1)