Cyclohexylamine → HCID 178450072, compound

HRID 480489Notes

Reaction equation

HRID 480489 reaction equation
[OH:1][C:2]([C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][CH:39]=1)[CH:36]=[C:35]([C:40](OC)=[O:41])[CH:34]=[CH:33]2)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].OC(C1C=C2C(=CC=1)C=C(C(O)=O)C=C2)(C1N=CN(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1)C(C)C.[CH:86]1([NH2:92])[CH2:91][CH2:90][CH2:89][CH2:88][CH2:87]1>>[CH:86]1([NH:92][C:40]([C:35]2[CH:34]=[CH:33][C:32]3[C:37](=[CH:38][CH:39]=[C:30]([C:2]([OH:1])([C:6]4[N:7]=[CH:8][NH:9][CH:10]=4)[CH:3]([CH3:4])[CH3:5])[CH:31]=3)[CH:36]=2)=[O:41])[CH2:91][CH2:90][CH2:89][CH2:88][CH2:87]1

Participants

4

Reactant 3

HCID 7965CyclohexylamineHCID 187691016-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acidHCID 22285069methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate

Product 1

HCID 178450072HCID 178450072, compound

Procedure

In a manner to that described in Example 9-(i), methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate (2.83 g) was converted to 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid, which was reacted with cyclohexylamine (0.18 mL) in a similar manner as described in Example 24-(i) to give the titled compound (598 mg) as a colorless powder.

Sources & evidence

ORD record
ord-f98f1ba1376d417280ca9c221df0f07e
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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