HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl D-alaninate hydrochloride → HCID 178501480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl D-alaninate hydrochloride | HCID 11182647 | — |
| Reactant | 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid | HCID 18769101 | — |
| Reactant | methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate | HCID 22285069 | — |
| Product | HCID 178501480 | HCID 178501480 | 143.3% |
Reaction Steps
In a manner to that described in Example 9-(i), methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate (622 mg) was converted to 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid, which was reacted with D-alanine methyl ester hydrochloride (283 mg) in a similar manner as described in Example 24-(i) to give the titled compound (622 mg) as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06649643B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-453faf68eb55434e87c7a536366ba173 |
| Source note | uspto-grants-2003_11 |