Butyl Acetate → HCID 18764693, compound

HRID 480524Notes

Reaction equation

HRID 480524 reaction equation
[NH2:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[C:3]([OH:5])=[O:4].[C:15](OCCCC)(=[O:17])[CH3:16]>>[C:15]([NH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[C:3]([OH:5])=[O:4])(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 31272Butyl AcetateHCID 3079222-Aminoundecanoic acid

Product 1

HCID 18764693HCID 18764693, compound

Procedure

20.1 parts of aminoundecanoic acid and 116.2 parts of butyl acetate were placed in a reactor equipped with a thermometer, a thermostat, a stirrer and a condenser, and allowed to react at 120° C. for 8 hours while azeotropically distilling off butanol. Further, 58.1 parts of butyl acetate was added, and allowed to react at 120° C. for 3 hours. Butanol and excess butyl acetate were distilled off under reduced pressure, thus giving an acetoamidoundecanoic acid. Then, 48.6 parts of the obtained acetoamidoundecanoic acid, 345 parts of dodecanoic diacid and 326.4 parts of acetic anhydride were placed in a reactor equipped with a thermometer, a thermostat, a stirrer and a condenser, and heated to 170° C. with stirring while distilling off acetic acid. After the distillation of acetic acid ceased, pressure was reduced to 30 mmHg at 170° C., followed by cooling the reaction mixture, thus giving an acid anhydride (a-4).

Workup

  1. customequipped with a thermometer
  2. customto react at 120° C. for 8 hours
  3. distillationwhile azeotropically distilling off butanol
  4. additionFurther, 58.1 parts of butyl acetate was added
  5. customto react at 120° C. for 3 hours
  6. distillationButanol and excess butyl acetate were distilled off under reduced pressure

Sources & evidence

ORD record
ord-e5ae64faa9844cb3adbdb50ce37e4568
Source dataset
uspto-grants-2003_11
Patent number
US06652917B2

Reaction notes

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