tert-Butyl piperazine-1-carboxylate → 7-(4-t-Butyloxycarbonyl-1-piperazinesulfonyl)-1,2,3,4-tetrahydroisoquinoline

Participants

Reaction Steps

The subtitle compound was prepared by the method of Example 16(a) from 1-t-butyloxycarbonylpiperazine and 2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride. The product was purified on silica gel, eluting with CH2Cl2/MeOH (93/7, v/v) to afford the subtitle compound (35%) as a colourless solid. Rf 0.56 (CH2Cl2/MeOH 9/1, v/v). MS m/z 382 (MH+).

Provenance & Evidence