Nitrogen → 1-Methoxy-2-nitro-3-(2-nitroprop-1-en-1-yl)benzene

Participants

Reaction Steps

To a 5 L three-necked round-bottomed flask equipped with a mechanical stirrer and a N2 bubbler were added 1-(2-nitro-3-methoxyphenyl)-2-nitropropanol (170 g, 0.66 mol), acetic anhydride (450 mL), 18-Crown-6 (17 g) and KF (38.25 g). The reaction mixture was stirred at RT for 64 h, then cooled in an ice-water bath. Water (2250 mL) was added slowly. The resulting slurry was stirred at 0° C. for 2 h and then filtered. The cake was washed with DI water (3×250 mL) and suction dried for 20 h to give 1-(2-nitro-3-methoxyphenyl)-2-nitropropene (150.7 g, 96% yield). 1H NMR (CDCl3) δ2.30 (s, 3H), 3.95 (s, 3H), 6.94 (d, J=7.8 Hz, 1H), 7.13 (d, J=8.5 Hz, 1H), 7.53 (pseudo t, J=8.1 Hz, 1H), 7.89 (s, 1H).

Provenance & Evidence