反应详情

4.60 g of [N-benzyl-N-(2-hydroxybutyl)amino]acetic acid are dissolved in a mixture of methanol and water (7:1) and hydrogenated in the presence of palladium (10% on activated charcoal) as catalyst for about 2.5 hours at ambient temperature until the calculated amount of hydrogen has been taken up. For working up, the catalyst is filtered off and the filtrate evaporated down in vacuo, leaving a white solid. Yield: 2.77 g (97% of theory); Rf value: 0.86 (Reversed phase ready-made TLC plate (E. Merck), acetonitrile/water/trifluoroacetic acid=50:50:1); mass spectrum (ESI−): m/z=146 [M−H]−.

1. filtrationthe catalyst is filtered off
2. customthe filtrate evaporated down in vacuo
3. customleaving a white solid