関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| 反応物 | 4-Chloro-2-phenoxymethylquinazoline | HCID 21991093 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 178420515 | HCID 178420515 | — |
反応手順
To a solution of the above 4-chloro-2-phenoxymethylquinazoline (0.5 g, 1.85 mmol) in THF (30 mL) is added 3-amino-5-cyclopropylpyrazole (0.47 g, 3.69 mmol) and the reaction mixture is heated at 65° C. for 24 hours. Solvent is evaporated and ethanol is added. A white solid forms and is collected by filtration and dried under vacuum to give (5-cyclopropyl-2H-pyrazol-3-yl)-(2-phenoxymethyl-quinazolin-4-yl)-amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06653300B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-e804edbac68246a886d97f64747c325c |
|---|
| 出典メモ | uspto-grants-2003_11 |
|---|
