Ethanol → HCID 178444743, compound

HRID 480659Notes

Reaction equation

HRID 480659 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4](Cl)[N:3]=1.[CH2:10]([NH2:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].C([OH:19])C>O>[NH2:1][C:2]1[N+:7]([O-:19])=[C:6]([NH:16][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 8102Hexylamine2×HCID 655222-Amino-4,6-dichloropyrimidine

Product 1

HCID 178444743HCID 178444743, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

50 g of 2-amino-4,6-dichloropyrimidine were suspended in 350 ml of absolute ethanol in a reactor. 181.5 ml of hexylamine (reagent A) were added in a single portion and the mixture was refluxed for 3 h. The medium was evaporated under vacuum. The oil obtained was taken up in 600 ml of water with stirring for 1 h, 30 min. The precipitate was filtered off, washed and dried in a heated desiccator. 43.5 g of the expected compound were thus obtained, for a yield of 62%.

Workup

  1. temperaturethe mixture was refluxed for 3 h
  2. customThe medium was evaporated under vacuum
  3. customThe oil obtained
  4. filtrationThe precipitate was filtered off
  5. washwashed
  6. customdried in a heated desiccator

Sources & evidence

ORD record
ord-246f9ea39ccd40e4867a8ee5905a2f69
Source dataset
uspto-grants-2003_11
Patent number
US06653317B2

Reaction notes

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