HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → HCID 69756244, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 18470676 | HCID 18470676 | — |
| Reactant | HCID 69754176 | HCID 69754176 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 69756244 | HCID 69756244 | 85% |
Reaction Steps
BOC-6-aminohexanoic acid (2.14 g, 9.25 mmol) was coupled to D-phenylalanine benzyl ester hydrochloride (2.7 g, 9.25 mmol) with Py-BOP in the presence of DIPEA, and the resulting product was hydrogenated in 95% ethanol at atmospheric pressure in the presence of 10% palladium over charcoal to afford BOC-6-aminohexanoyl-D-phenylalanine (3.35 g, 85%). The title compound was obtained by coupling BOC-6-aminohexanoyl-D-phenylalanine to Compound 2, deprotection and RP-HPLC as described for Compound 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653299B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-c48a4c2ced7f479f8659021dd0961516 |
| Source note | uspto-grants-2003_11 |