Tetrabutylammonium Fluoride → HCID 6474953, compound

Participants

Reaction Steps

A solution of 25 (278 mg, 0.499 mmol) in CH3CN (15 mL) was treated with tetra-n-butylammoniumfluorid (I M solution in THF) (0.6 mL, 0.6 mmol) at rt for 1 h. After concentration of the mixture, the residue was purified by silica gel column chromatography (CHCl3:MeOH, 20:1) to give 27 (151 mg, 95 as a white solid: mp 176-177° C.; [α]D+6.5 (c 0.47, MeOH); UV (MeOH) λmax 249.5 (ε 15600), 291.0 nm 11700) (pH 7), 248.5 (ε 16300), 291.5 nm (ε 11800) (pH 2), 253.5 (ε 16500), 284.5 nm (sh) (pH 11).

Provenance & Evidence