HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorophenylacetic acid → HCID 86584979, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| Reactant | HCID 69034686 | HCID 69034686 | — |
| Product | HCID 86584979 | HCID 86584979 | — |
Reaction Steps
Following General Procedure I above using 3,5-difluorophenylacetic acid (Lancaster) and 3-(L-alaninyl)-amino-2,4-dioxo-1,5-bis-(2,2-dimethylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-V), the title compound was prepared as a white solid (melting point=194-195° C.). Purification was by flash chromatography eluting with CH2Cl2/EtOAc (2:1 gradient to 3:2). Rf=0.46 (CH2Cl2/EtOAc, 2:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653303B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-a30dab310ffa4ea59b91073c38503066 |
| Source note | uspto-grants-2003_11 |