HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzonitrile → n-(4-Cyanophenyl)alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| Product | n-(4-Cyanophenyl)alanine iso-butyl ester | HCID 54547341 | — |
Reaction Steps
Following General Procedure AP above and using 4-fluorobenzonitrile (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example AA above), the title compound was prepared as an oil. The product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653303B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-ef9404d0405f4755a1be71a24800cd2e |
| Source note | uspto-grants-2003_11 |