HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Tolylacetic acid → N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Tolylacetic acid | HCID 248474 | — |
| Reactant | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| Product | N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester | HCID 22492098 | — |
Reaction Steps
Following General Procedure BB and using 4-methylphenylacetic acid (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653303B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-7a5508912658457888e5f570ee59dffc |
| Source note | uspto-grants-2003_11 |