3-Nitrophenylacetic acid → 2-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 480888Notes

Reaction equation

HRID 480888 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 539659122-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 3-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the tide compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customthe tide compound was prepared
  2. customThe reaction was monitored by tlc on silica gel and purification
  3. filtrationwas by filtration

Sources & evidence

ORD record
ord-d5ec4ea16fbd4bcba15e959d73583c27
Source dataset
uspto-grants-2003_11
Patent number
US06653303B1

Reaction notes

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