2-Naphthaleneacetic acid → 2-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

HRID 480890Notes

Reaction equation

HRID 480890 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][CH:16]([CH2:24][CH3:25])[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH2:24][CH3:25])[CH:21]([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 536358212-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-naphthylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-52d0257643be4155acafb9ee4673616b
Source dataset
uspto-grants-2003_11
Patent number
US06653303B1

Reaction notes

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