p-Toluenesulfonic acid monohydrate → HCID 178462396, compound

Participants

Reaction Steps

In the same manner as that described in Example 1(2), a reaction was carried out using 4′-cyano-4-formylbenzanilide (75 mg, 0.30 mmol) obtained in Example 2(1), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)butanol (98 mg, 0.27 mmol) and p-toluenesulfonic acid monohydrate (62 mg, 0.32 mmol) and the reaction mixture was treated using a similar procedure to that described in Example 1(2) to give the trans isomer of the title compound (30 mg, yield 19%) as a white solid and the cis isomer (20 mg, yield 12%) as a white solid. The trans isomer was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence