p-Toluenesulfonic acid monohydrate → HCID 178461714, compound

Participants

Reaction Steps

In the same manner as described in Example 1(2), a reaction was carried out using 4′-cyano-4-formylbenzanilide (78 mg, 0.31 mmol) obtained in Example 2(1), (4S,5R)-5-(2,4-difluorophenyl)-2-(hydroxymethyl)-4-methyl-6-(1H-1,2,4-triazol-1-yl)-1,5-hexanediol (disclosed in Japanese Patent Application Publication No. Hei-11-80135: 100 mg, 0.29 mmol) and p-toluenesulfonic acid monohydrate (99 mg, 0.52 mmol) and the reaction mixture was treated using a similar procedure to that described in Example 1(2) to give the trans isomer of the title compound (100 mg, yield 59%) as a white solid and the cis isomer (23 mg, yield 14%) as a colorless oil. The trans isomer was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence