4-Chloroaniline → 4'-Chloro-4-formylbenzanilide

Participants

Reaction Steps

In the same manner as that described in Example 2(1) a reaction was carried out using commercially available 4-chloroaniline (354 mg, 2.8 mmol), triethylamine (0.7 ml, 5.0 mmol), 4-formylbenzoyl chloride (700 mg, 4.2 mmol) and 4-(dimethylamino)pyridine (a catalytic amount) and the reaction mixture was treated according to a similar procedure to that described in Example 2(1) to afford 4′-chloro-4-formylbenzanilide (489 mg, yield 68%) as a white solid which was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence