Triethylamine → 4-Formyl-4'-(trifluoromethyl)benzanilide

Participants

Reaction Steps

In the same manner as that described in Example 2(1), a reaction was carried out using commercially available 4-(trifluoromethyl)aniline (446 mg, 2.8 mmol), triethylamine (0.6 ml, 4.4 mmol), 4-formylbenzoyl chloride (700 mg, 4.2 mmol) and 4-(dimethylamino)pyridine (a catalytic amount) and the reaction mixture was treated according to a similar procedure to that described in Example 2(1) to afford 4-formyl-4′-(trifluoromethyl)benzanilide (577 mg, yield 71%) as a white solid which was recrystallized from ethyl acetate-hexane to give white fluffy crystals.

Provenance & Evidence