p-Toluenesulfonic acid monohydrate → HCID 178462392, compound

Participants

Reaction Steps

In the same manner as that described in Example 3(3), a reaction was carried out using 4-formyl-4′-(trifluoromethyl)benzanilide (300 mg, 1.0 mmol), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol (334 mg, 0.93 mmol) and p-toluenesulfonic acid monohydrate (318 mg, 1.7 mmol) and the reaction mixture was treated according to a similar procedure to that described in Example 3(3) to give the trans isomer of the title compound (275 mg, yield 47%) as a white solid and the cis isomer (58 mg, yield 10%) as a colorless oil. The trans isomer was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence