p-Toluenesulfonic acid monohydrate → HCID 178462405, compound

Participants

Reaction Steps

In the same manner as that described in Example 3(3), a reaction was carried out using 4-formyl-N-(4-pyridyl)benzamide (200 mg, 0.88 mmol), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol (318 mg, 0.88 mmol) and p-toluenesulfonic acid monohydrate (469 mg, 2.5 mmol) and the reaction mixture was treated according to a similar procedure to that described in Example 3(3) to give the trans isomer of the title compound (187 mg, yield 37%) as a white solid and the cis isomer (86 mg, yield 17%) as a colorless oil. The trans isomer was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence