4-Amino-2,3,5,6-tetrafluorobenzonitrile → HCID 178462406, compound

Participants

Reaction Steps

In the same manner as that described in Example 3(4), a reaction was carried out using commercially available 4-amino-2,3,5,6-tetrafluorobenzonitrile (227 mg, 1.2 mmol), trimethylaluminium (1.1 ml, 1.07M n-hexane solution, 1.2 mmol) and methyl 4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]benzoate (150 mg, 0.30 mmol), obtained in Example 12(1), and the reaction mixture was treated using a similar procedure to that described in Example 3(4) to afford the title compound (84 mg, yield 42%) as a colorless oil which was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence