p-Toluenesulfonic acid monohydrate → HCID 178466749, compound

Participants

Reaction Steps

In the same manner as that described in Example 3(3), a reaction was carried out using 4′-acetyl-4-formylbenzanilide (200 mg, 0.75 mmol), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol (256 mg, 0.71 mmol) and p-toluenesulfonic acid monohydrate (243 mg, 1.3 mmol) and the reaction mixture was treated according to a similar procedure to that described in Example 3(3) to give the trans isomer of the title compound (280 mg, yield 65%) as a white solid which was recrystallized from ethyl acetate-hexane to give white powdery crystals.

Provenance & Evidence