p-Toluenesulfonic acid monohydrate → HCID 178462407, compound

Participants

Reaction Steps

In the same manner as that described in Example 1(2), a reaction was carried out using 4-formyl-N-(2-thiazolyl)benzamide, obtained in Example 27(1) (200 mg, 0.86 mmol), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol (270 mg, 0.75 mmol) and p-toluenesulfonic acid monohydrate (357 mg, 1.88 mmol) and the reaction mixture was treated using a similar procedure to that described in Example 1(2) to afford the trans isomer of the title compound (64 mg, yield 15%) as a white oil and the cis isomer (29 mg, yield 7%) as a colorless oil. The trans isomer was recrystallized from tetrahydrofuran-hexane to give white powdery crystals.

Provenance & Evidence