3,4-dihydro-2H-pyran → HCID 22026143, compound

Participants

Reaction Steps

1-(2,5-Dihydroxy-3,4-dimethyl-phenyl)-ethanone of Step 3 (275 mg) was dissolved in dichloromethane (20 mL) and 3,4-dihydro-2H-pyran (0.2 mL) was added followed by pyridinium p-toluenesulfonate (PPTS) (30 mg). The mixture was stirred at room temperature for 4 h. The mixture was dried over MgSO4 and purified on silica gel column eluting with 30% EtOAc in hexane to give 397 mg of 1-[2-hydroxy-3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone as a yellow solid.

Provenance & Evidence