Triethylamine → HCID 18765927, compound

Participants

Reaction Steps

To a stirred solution of dimethyl 2-[2-(2-aminophenyl)ethyl]-4-(2,6-dichlorophenyl)-6-(2-methoxy-2-oxoethyl)-1,4-dihydro-3,5-pyridinedicarboxylate (500 mg/0.94 mmol) and methanesulfonyl chloride (107 mg/0.94 mmol) in anhydrous CH2Cl2(15 ml) was added triethylamine (94.7 mg/0.94 mmol) at 0° C. under nitrogen atmosphere. The resulting solution was stirred at room temperature for 1 day. The reaction was quenched with water and the separated organic layer was washed with water and brine, dried over MgSO4, filtered and concentrated to afford a crude mixture. This crude was purified by column chromatography on silica gel (Hexane:EtOAc=3:2) to afford a yellow solid (262 mg/46%).

Provenance & Evidence