Water → HCID 18765857, compound

Participants

Reaction Steps

To a solution of dimethyl 2-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethyl]-4-(2,6-dichlorophenyl)-6-(2-methoxy-2-oxoethyl)-1,4-dihydro-3,5-pyridinedicarboxylate (example 5, 3.90 g/6.01 mmol) in THF (39 ml) was added a solution of tetrabutylammonium fluoride (6.0 ml/6.0 mmol) at 0° C. and the resulting solution was stirred for 30 min at room temperature. The mixture was poured into water. The whole was extracted with dichloromethane (100 ml×2). The combined organic layer was washed with brine (30 ml), dried over magnesium sulfate, filtered and concentrated. The residue was purified by column chromatography (SiO2, 200-350 mesh/hexane:ethyl acetate=4:1-2:1) to afford a yellow oil (3.20 g/99%).

Provenance & Evidence