2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 18765910, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of dimethyl 4-(2,6-dichlorophenyl)-2-(2-methoxy-2-oxoethyl)-6-[2-(2-nitrophenyl)ethyl]-1,4-dihydro-3,5-pyridinedicarboxylate (example 10, 1.56 g/2.92 mmol) and N,N-diisopropylethylamine (3.78 g/29.2 mmol) in toluene (50 ml) was added trifluoromethanesulfonic acid 2,2,2-trifluoroethyl ester (6.78 g/29.2 mmol) at room temperature. The reaction mixture was refluxed at 130° C. for 1 day. The reaction was quenched with water and the separated organic layer was washed with sat.NaHCO3 and brine, dried over MgSO4, filtered and concentrated to afford a crude mixture. This crude was purified by column chromatography on silica gel (Hexane:EtC,Ac=2:1) to afford a pale yellow oil (1.34 g/75%).

Provenance & Evidence