Triethylamine → HCID 18765894, compound

Participants

Reaction Steps

To an ice-cooled stirred solution of dimethyl 4-(2,6-dichlorophenyl)-2-[2-(2-{[2-(ethylamino)ethoxy]methyl}phenyl)ethyl]-6-(2-methoxy-2-oxoethyl)-1,4-dihydro-3,5-pyridinedicarboxylate (700 mg/1.13 mmol) in dichloromethane (50 ml) was added di-t-butyl carbonate (297 mg/1.36 mmol) and triethylamine (172 mg/1.70 mmol). The reaction mixture was warmed to room temperature and stirred for 1.5 h. The reaction mixture was quenched with water. The separated organic layer was washed with water, dried over MgSO4, filtered and concentrated to give a crude mixture. This crude was purified by column chromatography on silica gel (CH2Cl2:MeOH=40:1) to afford a yellow amorphous (813 mg/quant.).

Provenance & Evidence