HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → 8-Benzyloxy-6-ethoxycarbonyl-2,3-dimethylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 8-(Benzyloxy)-6-bromo-2,3-dimethylimidazo[1,2-a]pyridine | HCID 12106081 | — |
| Reactant | HCID 178418416 | HCID 178418416 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 8-Benzyloxy-6-ethoxycarbonyl-2,3-dimethylimidazo[1,2-a]pyridine | HCID 12106082 | — |
Reaction Steps
A mixture of 4 g of 8-benzyloxy-6-bromo-2,3-dimethylimidazo[1,2-a]pyridine, 0.4 g of palladium( acetate, 1.33 g of triphenylphosphine, 10 ml of triethylamine and 50 ml of ethanol is heated for 16 h) a carbon monoxide atmosphere in an autoclave (5 bar), the volatile portions are stripped off in vaco and the residue is chromatographed on silica gel (eluent: ethyl acetate). 2.4 g of the title compound melting point 140-1° C. (diethyl ether) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653477B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-67de1b14ab62478188cfb7eee16c6ff0 |
| Source note | uspto-grants-2003_11 |