HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroisatin | HCID 236566 | — |
| Solvent | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Product | 5-fluoro-1,3-dihydro-2H-indol-2-one | HCID 3731012 | 99.8% |
Reaction Steps
5-Fluoroisatin (8.2 g, 49.7 mmol) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1 hour. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried under vacuum oven to give 5-fluoro-2-oxindole (7.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653308B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-044d1f0578944584ba5f24db6d431ef1 |
| Source note | uspto-grants-2003_11 |